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    Home»Health»Covid-19 rebound probably more common than data suggests, but paxlovid still effective
    Health

    Covid-19 rebound probably more common than data suggests, but paxlovid still effective

    admin4By admin4August 26, 2022No Comments
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    However, some people taking paxlovid and those not have experienced rebound cases of Covid-19, with symptoms returning just days after completing treatment and receiving a negative result. or test positive.

    And recent high-profile rebounding incidents involving President Joe Biden, Dr. Anthony Fauci, and Mrs. Jill Biden have raised questions about how often this happens.

    “Based on the data we have so far, Covid-19 rebounds are relatively rare events that have not occurred in most cases,” a spokesperson for the U.S. Centers for Disease Control and Prevention told CNN. A small percentage of people infected with Covid-19 experience recurrences of symptoms, including those taking antiviral medications such as paxlovid.”

    Experts say rebound cases are probably more common than the data suggests, but it’s difficult to know exactly how much.

    There are various estimates of what that “small percentage” is, from less than 1% to more than 10% of people taking paxlobid, and definitions of rebound cases are inconsistent.

    CDC ends social distancing and quarantine recommendations for Covid-19 control, no longer recommends testing to stay in school
    and that “temporary relapses of symptoms are associated with the natural history of SARS-CoV-2 (the virus that causes COVID-19) infection in some individuals, independent of treatment with paxlovid and irrespective of vaccination status.” could be part of the,” said the health official. recommendations issued by the CDC.

    Dr. Michael Charness of the Center for Veterans Affairs in Boston says it’s important to have better insight into both individual patients and the wider community. Covid-19 relapsing after paxlovid treatment.

    It should be noted that people who experience rebound cases can be contagious and may need to be re-isolated according to CDC guidance. A positive result “can certainly be a cause for concern for many people who are wondering, ‘Why is this happening to me?'”

    Tracking the rebound of Covid-19

    In a clinical trial document submitted to the U.S. Food and Drug Administration last year, Pfizer said, “Several subjects appear to have restored SARS-CoV-2 RNA levels.” Their data showed that about 2% of people had a current or sustained rebound in viral load, and this percentage was higher in both the group he was treated with Paxlovid and the placebo group that was not. It was the same.

    Pfizer does not have additional data on rebound cases outside of clinical trials. These clinical trials were conducted at a time when Delta variants were prevalent and most people were unvaccinated.

    Coronavirus can be contagious during Pax Lovid's rebound, researchers warn, even if people don't have symptoms
    Preprint studies that followed rebound cases during the Omicron wave found that 2-4% of patients experienced rebound infections or symptoms within 1 week of treatment, and 5-6% rebounded within 1 month. I was.
    Another study, published in June by Mayo Clinic researchers, closely matches Pfizer’s clinical trial data. The researchers found that about 1% of patients treated with paxlovid experienced a recurrence of symptoms an average of about 9 days after treatment. The study was retrospective and could not determine whether patients had a positive reaction with recurrence of symptoms.

    But according to Aditya Shah, an infectious disease expert and author of the report, the true infection rate is probably closer to 10%.

    President Joe Biden formally cleared quarantine after Covid-19 case rebound

    “We have to acknowledge the limitations of doing this type of study: all of these patients stay home and not all patients with recurring symptoms contact their doctors,” Shah said. “Thus, our study clearly underestimated the real cases.”

    Chanes also estimates that Covid-19 rebound rates in vaccinated people who have taken Paxlovid are in a similar range, but uncertainties remain.

    “There’s no study that gives us a definite answer. It’s probably not 50%, maybe not 2%,” he said. I wouldn’t be surprised if it’s in the 5-10% range of people who get treated.”

    Preliminary data suggest that people with comorbidities are more likely to experience rebound cases, according to the CDC. There is no strong evidence and more research is needed,” they said.

    “I apologize for the inconvenience caused by the rebound”

    Despite the potential for rebound, experts agree that Paxlovid is still an excellent treatment option.

    What to Know About Pax Lovid's Rebound? Our Medical Analyst Explains

    If rebound cases of Covid-19 are one cost for taking paxlobid, it needs to be weighed against the possible costs of not having treatment.

    The majority of people who have rebound cases of Covid-19 after taking paxlovid have been found to have mild symptoms. But it remains far from the level of serious illness that Pax Lovid was intended to protect against.

    “I think it’s important, especially for people who are at high risk of progression, to take paxlobid,” he said. But for almost all of them, rebounding will be an inconvenience, and that inconvenience is actually less important than the potential to avoid hospitalization and death.”

    President Biden and Fauci received a second course of Paxlovid to treat rebounding cases. And just this week, the FDA requested additional data from Pfizer to study patients who may need her second treatment.

    “We continue to monitor data from ongoing clinical studies and post-approval safety studies, although further evaluation is warranted,” Pfizer said in a statement. We are very confident in its clinical efficacy in preventing outcomes.”

    Overall, published data on paxlovid prescribing are lacking. According to the US Department of Health and Human Services, about 4 million courses of Paxlovid have been administered as of mid-August, but there are no additional details about the demographics or health status of those who have received them.

    Much work has been done on the rebound case, Charness said, but many questions remain.

    “I look back to February and March when this is something that is really not known and people who have experienced rebounds call their providers and are told as a test must be wrong,” he said. “From then to now, the information was very circulated. This is good, but people aren’t 100% sure what to do with it.”



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